Dmd064253 1341..1344
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چکیده
Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of therapeutic is crucial. Reported here is a method of enriching a specific organelle (lysosome) to understand the catabolism of an anti-CD70 Ab-MCC-DM1, an antibody drug conjugate with a noncleavable linker. With such techniques a higher degree of concentrationactivity relationship can be established for in vitro cell lines; this can aid in understanding the resultant catabolite concentrations necessary to exert activity.
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Dmd064253 1341..1344
Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of therapeutic is crucial. Reported here is a method of enriching a specific organelle (lysosome) to understand the catabolism of an anti-CD70 Ab-MCC-DM1, an antibody drug conjugate with a noncleavable linker. With such tec...
متن کاملElectron density studies on quinoline analogs of N, N'-dimethyl-p-phenylazoaniline.
This paper continues the study of the relationship between electron density and carcinogenic activity for compounds related to p-dimethylaminoazobenzene (Cancer Res., 29: 1341-1344, 1969) and reports on the seven p-dimethylaminophenylazoquinolines. A relationship was found between carcinogenic activity and the pKfl of the amino nitrogen in these compounds, and in this new series a relationship ...
متن کاملClin Pharmacokinet 2003; 42 (15): 1331-1357
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1331 1. Nuclear Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1332 1.1 Orphan Receptors . . . . . . . . . . . . . . . . . . . . ....
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(a) This part implements procedures under section 806 of the Corporate and Criminal Fraud Accountability Act of 2002, Title VIII of the Sarbanes-Oxley Act of 2002 (‘‘Sarbanes-Oxley’’ or ‘‘Act’’), enacted into law July 30, 2002. Sarbanes-Oxley provides for employee protection from discrimination by companies and representatives of companies because the employee has engaged in protected activity ...
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